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TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. [5]
After cyclic GMP-AMP bound STING is activated, it enhances TBK1's activity to phosphorylate IRF3 and STAT6 for downstream type I interferon response. [28] [29] It has been proposed that intracellular calcium plays an important role in the response of the STING pathway. [30]
The cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP-AMP synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). cGAMP binds to Stimulator of Interferon Genes which triggers phosphorylation of IRF3 via TBK1.
TRIF activates the kinases TBK1 and RIPK1, which creates a branch in the signaling pathway. The TRIF/TBK1 signaling complex phosphorylates IRF3 allowing its translocation into the nucleus and production of interferon type I. Meanwhile, activation of RIPK1 causes the polyubiquitination and activation of TAK1 and NFκB transcription in the same ...
The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K ( phosphatidylinositol 3-kinase ) and Akt ( protein kinase B ).
TBK1 may refer to: TANK-binding kinase 1, an enzyme; IkappaB kinase, an enzyme This page was last edited on 30 December 2019, at 15:16 (UTC). Text is available under ...
c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain.. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic s
21353 Ensembl ENSG00000136560 ENSMUSG00000064289 UniProt Q92844 Q6NW12 P70347 RefSeq (mRNA) NM_001199135 NM_004180 NM_133484 NM_001164071 NM_001164072 NM_011529 NM_001355267 NM_001355268 NM_001374667 NM_001378922 RefSeq (protein) NP_001186064 NP_004171 NP_597841 NP_001186064.1 NP_001157543 NP_001157544 NP_035659 NP_001342196 NP_001342197 NP_001361596 NP_001365851 Location (UCSC) Chr 2: 161.14 ...