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SR9009, also known as Stenabolic, is a research drug that was developed by professor Thomas Burris of the Scripps Research Institute as an agonist of Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA) [1] with a half-maximum inhibitory concentration (IC 50) = 670 nM for Rev-ErbAα and IC 50 = 800 nM for Rev-ErbAβ. [2]
Moreover, 3-hydroxymethyl-beta-carboline blocks the sleep-promoting effect of flurazepam in rodents and – by itself – can decrease sleep in a dose-dependent manner. [16] Another derivative, methyl-β-carboline-3-carboxylate, stimulates learning and memory at low doses but can promote anxiety and convulsions at high doses. [15]
PRL-8-53 is a nootropic substituted phenethylamine that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.
N-Methyl-3-piperidyl benzilate (JB-336, BZ) Piperidine is also commonly used in chemical degradation reactions, such as the sequencing of DNA in the cleavage of particular modified nucleotides. Piperidine is also commonly used as a base for the deprotection of Fmoc-amino acids used in solid-phase peptide synthesis.
Usually aminomethyl groups feature tertiary amines. Often they are obtained by alkylation with Eschenmoser's salt, a source of [CH 2 =N(CH 3) 2] +. A cobalt(III) complex of aminomethyl is known in the form [Co 2 (CH 2 NH 2)](ClO4) 2. [1] Aminomethyl is the first member of a series of 1-aminoalkyl groups of the form −(CH 2 −) n NH 2. [2]
Most proteins and peptides contain both alcohols and amino groups. Two amino acids are alkanolamines, formally speaking: serine and hydroxyproline. Veratridine and veratrine; Tropane alkaloids such as atropine; hormones and neurotransmitters epinephrine (adrenaline) and norepinephrine (noradrenaline)
3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is used in the manufacture of six commercial fungicides which are inhibitors of succinate dehydrogenase. [20] [21] Pyrazole is an inhibitor of the alcohol dehydrogenase enzyme, and, as such, is used as an adjuvant with ethanol, to induce alcohol dependency in experimental laboratory mice ...
3-Picoline is a useful precursor to agrochemicals, such as chlorpyrifos. [1] Chlorpyrifos is produced from 3,5,6-trichloro-2-pyridinol, which is generated from 3-picoline by way of cyanopyridine. This conversion involves the ammoxidation of 3-methylpyridine: CH 3 C 5 H 4 N + 1.5 O 2 + NH 3 → NCC 5 H 4 N + 3 H 2 O
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