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From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $125 billion in sales over approximately 14.5 years. [ 115 ] and $13 billion a year at its peak, [ 116 ] Lipitor alone "provided up to a quarter of Pfizer Inc.'s annual revenue for years."
In February 2017, Morgan Griffith, a Virginia Republican, introduced H.R. 714, Legitimate Use of Medicinal Marijuana Act, that would move cannabis to Schedule II. [81] Griffith had introduced a bill under the same name in 2014. [82] In April 2017, Matt Gaetz, a Florida Republican, cosponsored House Resolution 2020 to move cannabis to Schedule III.
16007392. KEGG. D10385. Ezetimibe/atorvastatin (trade names Liptruzet, Atozet) is a cholesterol lowering combination drug. In the United States, it was approved in May 2013, by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Countries have an obligation to provide access and sufficient availability of drugs listed in Schedule I for the purposes of medical uses. [129] [130] Prior to December 2020 cannabis and cannabis resin were also included in Schedule IV, a more restrictive level of control, which is for only the most dangerous drugs such as heroin and fentanyl ...
Persons taking gemfibrozil, a non-statin lipid-lowering drug Atorvastatin Combining gemfibrozil and a statin increases risk of rhabdomyolysis and subsequently kidney failure [62] [63] Persons taking the anticoagulant warfarin: Any statin The statin use may require that the warfarin dose be changed, as some statins increase the effect of ...
This is the list of Schedule V controlled substances in the United States as defined by the Controlled Substances Act. [ 1 ] The following findings are required for substances to be placed in this schedule: [ 2 ] The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule IV. The drug or other ...
In the United States, cannabis is legal in 38 of 50 states for medical use and 24 states for recreational use. At the federal level, cannabis is classified as a Schedule I drug under the Controlled Substances Act, determined to have a high potential for abuse and no accepted medical use, prohibiting its use for any purpose. [ 1 ]
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