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Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. [ 3 ] [ 4 ] It is administered orally for constipation, and either orally or rectally for hepatic encephalopathy . [ 3 ]
[4] [23] Lactulose does not appear to be more effective than lactitol for treating people with hepatic encephalopathy. [23] Side effects of lactulose and lactitol include the possibility of diarrhea, abdominal bloating, gassiness, and nausea. [23] In acute liver failure, it is unclear whether lactulose is beneficial.
Acidification of the intestinal lumen using lactulose can decrease ammonia levels by protonating ammonia and trapping it in the stool. This is a treatment for hepatic encephalopathy. This is a treatment for hepatic encephalopathy.
Lactulose can be considered at this stage. A preliminary report from the ALFSG on 117 patients suggests that use of lactulose in the first 7 days after diagnosis is associated with a small increase in survival time, but with no difference in severity of encephalopathy or in the overall outcome.
Encephalopathy is a brain disorder that alters the brain function or structure, leaving you confused and not acting like your usual self.. Encephalopathy can be caused by a number of different ...
Lactulose works by the osmotic effect, which retains water in the colon; lowering the pH through bacterial fermentation to lactic, formic, and acetic acids; and increasing colonic peristalsis. Lactulose is also indicated in portal-systemic encephalopathy.
Mild hepatic encephalopathy (also known as covert hepatic encephalopathy), in which symptoms are more subtle, such as impairments in executive function, poor sleep or balance impairment is also associated with a higher risk of hospitalization and death (18% in those with covert hepatic encephalopathy vs 3% in those with cirrhosis and no HE). [59]
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