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Neuromyelitis optica (NMO) is a particular disease within the NMOSD spectrum. It is characterised by optic neuritis and longitudinally extensive myelitis. In more than 80% of NMO cases, the cause is immunoglobulin G autoantibodies to aquaporin 4 ( anti-AQP4 ), the most abundant water channel protein in the central nervous system.
In neuromyelitis optica higher AQP4 autoantibody levels are associated with the occurrence of optic neuritis. [16] Less common causes are: papilledema, brain tumor or abscess in the occipital region, cerebral trauma or hemorrhage, meningitis, arachnoidal adhesions, sinus thrombosis, liver dysfunction, or late stage kidney disease.
Neuromyelitis optica spectrum disorder Myasthenia Gravis The one and a half syndrome is a rare weakness in eye movement affecting both eyes, in which one cannot move laterally at all, and the other can move only in outward direction.
Most patients are seronegative for NMO-IgG and GFAP, biomarkers for neuromyelitis optica. [3] ANA, indicative of autoimmune optic neuropathy, is also generally negative. [3] CSF can also be evaluated for oligoclonal bands typical of multiple sclerosis, which will not be present in CRION. [1]
Multiple sclerosis and Neuromyelitis optica are autoimmune diseases which both frequently present with optic neuritis, an inflammatory demyelinating neuropathy of the optic nerve. [3] Multiple sclerosis is a disease of unknown etiology which is characterized by neurological lesions "disseminated in time and space". [24]
An ocular manifestation of a systemic disease is an eye condition that directly or indirectly results from a disease process in another part of the body. There are many diseases known to cause ocular or visual changes.
Cases of norovirus — the virulent, wildly contagious virus that causes vomiting and diarrhea — are increasing in the U.S., the Centers for Disease Control says, reporting double the amount of ...
Neuromyelitis optica (Devic's disease)/NMOSD: Optic nerves and spinal cord AQP4-IgG (NMO-IgG) Confirmed 0.5 - 4 per 100,000 [66] Restless legs syndrome: Central nervous system (thought to involve dopaminergic pathways) Unknown Uncertain 5-15% (more common in older adults) [67] Stiff-person syndrome: Central nervous system Anti-GAD, anti-amphiphysin
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