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Independent assortment occurs in eukaryotic organisms during meiotic metaphase I, and produces a gamete with a mixture of the organism's chromosomes. The physical basis of the independent assortment of chromosomes is the random orientation of each bivalent chromosome along the metaphase plate with respect to the other bivalent chromosomes.
In this example, the recombination frequency is 50% since 2 of the 4 gametes were recombinant gametes. [citation needed] The recombination frequency will be 50% when two genes are located on different chromosomes or when they are widely separated on the same chromosome. This is a consequence of independent assortment. [citation needed]
Meiosis generates gamete genetic diversity in two ways: (1) Law of Independent Assortment. The independent orientation of homologous chromosome pairs along the metaphase plate during metaphase I and orientation of sister chromatids in metaphase II, this is the subsequent separation of homologs and sister chromatids during anaphase I and II, it ...
In the example pictured to the right, RRYY/rryy parents result in F 1 offspring that are heterozygous for both R and Y (RrYy). [4] This is a dihybrid cross of two heterozygous parents. The traits observed in this cross are the same traits that Mendel was observing for his experiments. This cross results in the expected phenotypic ratio of 9:3:3:1.
This principle of "independent assortment" of genes is fundamental to genetic inheritance. [28] However, the frequency of recombination is actually not the same for all gene combinations. This leads to the notion of "genetic distance", which is a measure of recombination frequency averaged over a (suitably large) sample of pedigrees.
Most recombination occurs naturally and can be classified into two types: (1) interchromosomal recombination, occurring through independent assortment of alleles whose loci are on different but homologous chromosomes (random orientation of pairs of homologous chromosomes in meiosis I); & (2) intrachromosomal recombination, occurring through ...
Later, Eleanor Carothers documented definitive evidence of independent assortment of chromosomes in a species of grasshopper. [15] Debate continued, however, until 1915 when Thomas Hunt Morgan's work on inheritance and genetic linkage in the fruit fly Drosophila melanogaster provided incontrovertible evidence for the proposal.
The second, the law of independent assortment, states that "alleles of different genes assort independently of one another during gamete formation". Although his work was published, it lay dormant until it was rediscovered in 1900 by Hugo de Vries and Carl Correns but it was not until 1909 that non-mendelian inheritance was even suggested.