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The interthalamic adhesion (also known as the massa intermedia, intermediate mass or middle commissure) is a flattened band of tissue that connects both parts of the thalamus at their medial surfaces. The medial surfaces form the upper part of the lateral wall to the third ventricle.
The loop involves connections between the cortex, the basal ganglia, the thalamus, and back to the cortex. It is of particular relevance to hyperkinetic and hypokinetic movement disorders , such as Parkinson's disease and Huntington's disease , [ 1 ] as well as to mental disorders of control, such as attention deficit hyperactivity disorder ...
Localization of function of the thalamus can be illustrated through vascular thalamic amnesia. The damage to the tuberothalmic territory appears to have the most extensive effects in relation to this form of amnesia by affecting functions of arousal and orientation, learning and memory, personality, and executive function. [6]
Mammillary bodies, and their projections to the anterior thalamus via the mammillothalamic tract, are important for recollective memory. [7] According to studies of rats with mammillary body lesions, damage to the medial mammillary nucleus lead to spatial memory deficits. [7]
The image shows dopaminergic pathways of the human brain in normal condition (left) and Parkinsons Disease (right). Red Arrows indicate suppression of the target, blue arrows indicate stimulation of target structure. (Pallidothalamic connections visible but not labeled, as red line from GPi to THA.)
Schematic of the HPA axis (CRH, corticotropin-releasing hormone; ACTH, adrenocorticotropic hormone) Hypothalamus, pituitary gland, and adrenal cortex The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus (a part of the brain located below the thalamus), the pituitary gland (a ...
Korsakoff syndrome stems from damage to the mammillary body, the mammillothalamic fasciculus or the thalamus. [ 68 ] [ 69 ] Fatal familial insomnia is a hereditary prion disease in which degeneration of the thalamus occurs, causing the patient to gradually lose their ability to sleep and progressing to a state of total insomnia , which ...
However, the trigeminal lemniscus also carries pain and temperature sensations from the contralateral orofacial region, just as the spinothalamic tract carries these sensations from the contralateral body. Thus, the trigeminal lemniscus of the head is functionally analogous to both the DCML tracts and the spinothalamic tract of the body.