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The "68–95–99.7 rule" is often used to quickly get a rough probability estimate of something, given its standard deviation, if the population is assumed to be normal. It is also used as a simple test for outliers if the population is assumed normal, and as a normality test if the population is potentially not normal.
The approximate value of this number is 1.96, meaning that 95% of the area under a normal curve lies within approximately 1.96 standard deviations of the mean. Because of the central limit theorem, this number is used in the construction of approximate 95% confidence intervals. Its ubiquity is due to the arbitrary but common convention of using ...
About 68% of values drawn from a normal distribution are within one standard deviation σ from the mean; about 95% of the values lie within two standard deviations; and about 99.7% are within three standard deviations. [8] This fact is known as the 68–95–99.7 (empirical) rule, or the 3-sigma rule.
The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
An estimate of the standard deviation for N > 100 data taken to be approximately normal follows from the heuristic that 95% of the area under the normal curve lies roughly two standard deviations to either side of the mean, so that, with 95% probability the total range of values R represents four standard deviations so that s ≈ R/4.
This probability is given by the integral of this variable's PDF over that range—that is, it is given by the area under the density function but above the horizontal axis and between the lowest and greatest values of the range. The probability density function is nonnegative everywhere, and the area under the entire curve is equal to 1.
These values are used to calculate an E value for the estimate and a standard deviation (SD) as L-estimators, where: E = (a + 4m + b) / 6 SD = (b − a) / 6. E is a weighted average which takes into account both the most optimistic and most pessimistic estimates provided. SD measures the variability or uncertainty in the estimate.
The values within the table are the probabilities corresponding to the table type. These probabilities are calculations of the area under the normal curve from the starting point (0 for cumulative from mean, negative infinity for cumulative and positive infinity for complementary cumulative) to Z.