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Significant toxicity from benzodiazepines can occur in the elderly as a result of long-term use. [112] Benzodiazepines, along with antihypertensives and drugs affecting the cholinergic system, are the most common cause of drug-induced dementia affecting over 10 percent of patients attending memory clinics.
However, a prolonged and severe withdrawal syndrome can cause profound disability, which may lead to breakdown of relationships, loss of employment, financial difficulties, as well as more serious adverse effects such as hospitalization and suicide. [48] As such, long-term users should not be forced to discontinue against their will. [25]
However, drowsiness and tolerance become problems with continued use and none are now considered first-line choices for long-term epilepsy therapy. [53] Clobazam is widely used by specialist epilepsy clinics worldwide and clonazepam is popular in the Netherlands, Belgium and France. [53] Clobazam was approved for use in the United States in 2011.
A box of Lorazepam Orion (Lorazepam) tablets. Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. [14] It is used to treat anxiety (including anxiety disorders), trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy-induced nausea and vomiting. [14]
Benzodiazepines can cause side effects, including some that may affect your alertness, physical health and daily life. Common side effects of benzodiazepines include: Drowsiness
Failure to treat benzodiazepine dependence in the elderly can cause serious medical complications. [14] The elderly have less cognitive reserve and are more sensitive to the short (e.g., in between dose withdrawal) and protracted withdrawal effects of benzodiazepines, as well as the side-effects both from short-term and long-term use.
Winter brings less daylight and colder temperatures, which can disrupt sleep. Seasonal Affective Disorder (SAD) is more common in winter due to the lack of sunlight, causing sleep disturbances.
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