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The European Society of Cardiology (ESC), [21] and National Institute for Health and Care Excellence (NICE) [23] guidelines recommend that if the patient has a CHA 2 DS 2-VASc score of 2 and above, oral anticoagulation therapy (OAC) with a vitamin K antagonist (VKA, e.g. warfarin with target INR of 2-3) or one of the direct oral anticoagulant ...
2147 14061 Ensembl ENSG00000180210 ENSMUSG00000027249 UniProt P00734 P19221 RefSeq (mRNA) NM_000506 NM_001311257 NM_010168 RefSeq (protein) NP_000497 NP_034298 Location (UCSC) Chr 11: 46.72 – 46.74 Mb Chr 2: 91.46 – 91.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Role of thrombin in the blood coagulation cascade Prothrombin (coagulation factor II) is encoded in the human by ...
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]
"The Flesch–Kincaid" (F–K) reading grade level was developed under contract to the U.S. Navy in 1975 by J. Peter Kincaid and his team. [1] Related U.S. Navy research directed by Kincaid delved into high-tech education (for example, the electronic authoring and delivery of technical information), [2] usefulness of the Flesch–Kincaid readability formula, [3] computer aids for editing tests ...
Coumarin (/ ˈ k uː m ər ɪ n /) or 2H-chromen-2-one is an aromatic organic chemical compound with formula C 9 H 6 O 2.Its molecule can be described as a benzene molecule with two adjacent hydrogen atoms replaced by an unsaturated lactone ring −(CH)=(CH)−(C=O)−O−, forming a second six-membered heterocycle that shares two carbons with the benzene ring.
Warfarin is the preferred, and best studied anticoagulant, but direct factor Xa inhibitors may also be used. [2] Many patients will require further intervention. Some forms of Budd–Chiari may be treated with surgical shunts (such as portacaval shunt) to divert blood flow around the obstruction or the liver itself.
20310 Ensembl ENSG00000163739 ENSMUSG00000058427 UniProt P09341 P10889 RefSeq (mRNA) NM_001511 NM_009140 RefSeq (protein) NP_001502 NP_033166 Location (UCSC) Chr 4: 73.87 – 73.87 Mb Chr 5: 91.05 – 91.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small peptide belonging to the CXC chemokine family that acts as a ...
Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene. [5] [6]Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume.
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