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It was first identified in 1966 at the Mayo Clinic, by A.G. Engel, [2] and that same year W.K. Engel and J.S. Resnick noted another case that they elaborated in 1975. [3] [4] The diagnosis of the disease rests on subacutely evolving weakness after age 40, normal to low CK level, a myopathic EMG with fibrillations, and often a monoclonal gammopathy.
Benign acute childhood myositis (BACM) is a syndrome characterized by muscle weakness and pain in the lower limbs that develop in children after a recent viral illness. It is transient with a spontaneous clinical resolution within 1 week.
The management of lipodermatosclerosis may include treating venous insufficiency with leg elevation and elastic compression stockings. [9] In some difficult cases, the condition may be improved with the additional use of the fibrinolytic agent, stanozol.
Delandistrogene moxeparvovec (Elevidys) is a gene therapy that in June 2023 received United States FDA accelerated approval for the treatment of four and five-year-old children. [55] [56] In October 2023, the US Food and Drug Administration (FDA) approved Vamorolone (Agamree) as a Treatment for Duchenne muscular dystrophy.
Treatment should be continued as long as positive results occur. Once treatment is stopped, hair loss resumes. [32] Corticosteroids injections into the scalp can be used to treat alopecia areata. This type of treatment is repeated on a monthly basis. Oral pills for extensive hair loss may be used for alopecia areata.
Lipedema was first identified in the United States, at the Mayo Clinic, in 1940. [ 32 ] [ 33 ] Most attribute the original identification of lipedema to E. A. Hines and L. E. Wold (1951). [ 32 ] Despite that, lipedema is barely known in the United States to physicians or to the patients who have the disease.
Malan syndrome is defined by initial overgrowth and mild-to-severe intellectual disability. Almost all individuals with Malan syndrome display above-average height, weight, and head circumference in early life, but only one-third of adults with Malan syndrome are >2 standard deviations above the mean.
A seborrheic keratosis is a non-cancerous skin tumour that originates from cells, namely keratinocytes, in the outer layer of the skin called the epidermis.Like liver spots, seborrheic keratoses are seen more often as people age.