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Sulfanilamide is a yellowish-white or white crystal or fine powder. It has a density of 1.08 g/cm 3 and a melting point of 164.5-166.5 °C. The pH of a 0.5% aqueous solution of Sulfanilamide is 5.8 to 6.1. It has a λ max of 255 and 312 nm. [5] Solubility: One gram of sulphanilamide dissolves in approximately 37 ml alcohol or in 5 ml acetone.
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group.
Sulfamethoxazole, a sulfanilamide, is a structural analog of para-aminobenzoic acid (PABA). They compete with PABA to bind to dihydropteroate synthetase and inhibit conversion of PABA and dihydropteroate diphosphate to dihydrofolic acid, or dihydrofolate.
[5] This method can be applied in many aspects, including determining the nitrate/nitrite concentrations in sewage or other biological samples such as intracellular fluids, given that the sample is clear and colorless. In a similar protocol, the levels of sulfonamide in blood can be detected similarly with the same principles.
This page was last edited on 4 November 2024, at 18:09 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Under the deal announced on Friday, Merck will take a pretax charge of $5.5 billion, or about $1.70 per share, resulting in a reduction in fourth-quarter and full-year 2023 results, the companies ...
Dihydropteroate synthase inhibitors are drugs that inhibit the action of dihydropteroate synthase.They include sulfonamides, dapsone, and para-aminosalicylic acid. [1] ...
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