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2. Clonidine - Wikipedia

   en.wikipedia.org/wiki/Clonidine

   Clonidine may improve symptoms of attention deficit hyperactivity disorder in some people but causes many adverse effects and the beneficial effect is modest. [22] In Australia, clonidine is an accepted but not approved use for ADHD by the TGA. [23] Clonidine, along with methylphenidate, has been studied for treatment of ADHD.

3. Serotonin–norepinephrine–dopamine reuptake inhibitor

   en.wikipedia.org/wiki/Serotonin–norepinephrine...

   Chronic desipramine treatment in rats decreased the sensitivity of α 2-adrenoceptors, a finding supported by the fact that clonidine administration caused a significant increase in growth hormone (an indirect measure of α 2-adrenoceptor activity) although platelet studies proved inconsistent.

4. Somnifacient - Wikipedia

   en.wikipedia.org/wiki/Somnifacient

   It is not advisable to prescribe somnifacients for routine insomnia treatment, and they should only be used for short periods in patients who are severely distressed or with transient insomnia. [40] An important drawback of prolonged use is that it can result in rebound insomnia and withdrawal syndrome upon discontinuation. [ 40 ]

5. Doxepin for Depression, Insomnia & More: Everything You Need ...

   www.aol.com/doxepin-depression-insomnia-more...

   These receptors play a key role in the regulation of the body’s sleep-wake cycle, which is why, in 2010, the FDA approved the use of doxepin as a treatment for adults with insomnia. Doxepin is ...

6. Middle-of-the-night insomnia - Wikipedia

   en.wikipedia.org/wiki/Middle-of-the-night_insomnia

   Middle-of-the-night insomnia (MOTN), also called terminal Insomnia is characterized by having difficulty returning to sleep after waking up during the night or very early in the morning. This kind of insomnia (sleeplessness) is different from initial or sleep-onset insomnia, which consists of having difficulty falling asleep at the beginning of ...

7. Mirtazapine - Wikipedia

   en.wikipedia.org/wiki/Mirtazapine

   A single 15 mg dose of mirtazapine to healthy volunteers has been found to result in over 80% occupancy of the H 1 receptor and to induce intense sleepiness. [92] After a short period of chronic treatment, however, the H 1 receptor tends to sensitize and the antihistamine effects become more tolerable. Many patients may also dose at night to ...