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In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...
It plots serum concentration of acetaminophen against the time since ingestion, in order to predict possible liver toxicity and allow a clinician to decide whether to proceed with N-Acetylcysteine (NAC) treatment. It is a logarithmic graph starting 4 hours after ingestion; at this time the absorption of acetaminophen is considered likely to be ...
A graph depicting a typical time course of drug plasma concentration over 96 hours, with oral administrations every 24 hours. The main pharmacokinetic metrics are annotated. Steady state is reached after about 5 × 12 = 60 hours.
Reaction calorimetry may be classified as a differential technique since the primary data collected are proportional to rate vs. time. From these data, the starting material or product concentration over time may be obtained by simply taking the integral of a polynomial fit to the experimental curve.
Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. [4] AUC is used because AUC is proportional to the dose that has entered the systemic circulation. [5]
The name comes from the idea that on a graph of concentration versus time, the line forms a U-shaped trough at the lowest region, before a new dose sends it higher again. The usual criterion is concentration in the blood serum , although in some instances local concentration within tissues is relevant.
Central to PK/PD models is the concentration-effect or exposure-response relationship. [4] A variety of PK/PD modeling approaches exist to describe exposure-response relationships . PK/PD relationships can be described by simple equations such as linear model, Emax model or sigmoid Emax model . [ 5 ]
In medical imaging, a time-activity curve is a curve of radioactivity (in terms of concentration) plotted on the y-axis against the time plotted on the x-axis. It shows the concentration of a radiotracer within a region of interest in an image, measured over time from a dynamic scan. Generally, when a time-activity curve is obtained within a ...