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Iodine-123 (123 I) is a radioactive isotope of iodine used in nuclear medicine imaging, including single-photon emission computed tomography (SPECT) or SPECT/CT exams. The isotope's half-life is 13.2232 hours; [1] the decay by electron capture to tellurium-123 emits gamma radiation with a predominant energy of 159 keV (this is the gamma primarily used for imaging).
Sequence of 123-iodide human scintiscans after an intravenous injection, (from left) after 30 minutes, 20 hours, and 48 hours. A high and rapid concentration of radio-iodide is evident in extrathyroidal organs like cerebrospinal fluid (left), gastric and oral mucosa, salivary glands, arterial walls, ovary and thymus.
Sequence of 123-iodide human scintiscans after an intravenous injection, (from left) after 30 minutes, 20 hours, and 48 hours. A high and rapid concentration of radioiodide is evident in the periencephalic and cerebrospinal fluid (left), salivary glands, oral mucosa, and the stomach.
There are 40 known isotopes of iodine (53 I) from 108 I to 147 I; all undergo radioactive decay except 127 I, which is stable. Iodine is thus a monoisotopic element.. Its longest-lived radioactive isotope, 129 I, has a half-life of 16.14 million years, which is far too short for it to exist as a primordial nuclide.
Iodine-125 can be used in scanning/imaging the thyroid, but iodine-123 is preferred for this purpose, due to better radiation penetration and shorter half-life (13 hours). 125 I is useful for glomerular filtration rate (GFR) testing in the diagnosis or monitoring of patients with kidney disease .
Iofetamine (iodine-123, 123 I), brand names Perfusamine, SPECTamine), or N-isopropyl-(123 I)-p-iodoamphetamine (IMP), is a lipid-soluble amine and radiopharmaceutical drug used in cerebral blood perfusion imaging with single-photon emission computed tomography (SPECT).
The iodine introduced during manufacture is a radioactive isotope, iodine-123, and it is the gamma decay of this isotope that is detectable to a gamma camera. 123 I has a half-life of approximately 13 hours and a gamma photon energy of 159 keV making it an appropriate radionuclide for medical imaging. The solution also contains 5% ethanol to ...
In this protocol, iodide ion is generated by the following slow reaction between the iodate and bisulfite: IO − 3 + 3 HSO − 3 → I − + 3 HSO − 4. This first step is the rate determining step. Next, the iodate in excess will oxidize the iodide generated above to form iodine: IO − 3 + 5 I − + 6 H + → 3 I 2 + 3 H 2 O