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Clostridioides difficile (syn. Clostridium difficile) is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. [ 4 ] [ 5 ] It is known also as C. difficile , or C. diff ( / s iː d ɪ f / ), and is a Gram-positive species of spore -forming bacteria. [ 6 ]
Clostridioides difficile infection [5] (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection due to the spore-forming bacterium Clostridioides difficile. [6] Symptoms include watery diarrhea, fever, nausea, and abdominal pain. [1] It makes up about 20% of cases of antibiotic-associated diarrhea. [1]
The genus Clostridioides was created to describe a few species formerly in the genus Clostridium which have been shown to be their own genetically distinct genus using 16S rRNA gene sequencing analysis. [1] However, both names are still in use and valid under the International Code of Nomenclature of Prokaryotes. [2]
Bezlotoxumab is a human monoclonal antibody designed for the prevention of recurrence of Clostridium difficile infections. By x-ray crystallized structure of N-terminal of TcdB, the toxin is identified to consist of three domains: a glucosyltransferase domain (GTD), a cysteine protease and a combined repetitive oligopeptide (CROP) domain.
Clostridium is a genus of anaerobic, Gram-positive bacteria.Species of Clostridium inhabit soils and the intestinal tracts of animals, including humans. [1] This genus includes several significant human pathogens, including the causative agents of botulism and tetanus.
Clostridioides difficile toxin A (TcdA) is a toxin produced by the bacteria Clostridioides difficile, formerly known as Clostridium difficile. [1] It is similar to Clostridioides difficile Toxin B . The toxins are the main virulence factors produced by the gram positive , anaerobic, [ 2 ] Clostridioides difficile bacteria.
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