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Unlike the midbrain tectum (which is a sensory structure located posteriorly), the midbrain tegmentum, which locates anteriorly, is related to a number of motor functions. Within the tegmentum, the red nucleus is in charge of motor coordination (specifically for limb movements) and the periaqueductal gray matter (PAG) contains critical circuits ...
The most common drugs of abuse stimulate the release of dopamine, which creates both their rewarding and the psychomotor effects. Compulsive drug-taking behaviors are a result of the long-lasting or permanent [30] [31] functional changes in the mesolimbic dopamine system arising from repetitive dopamine stimulation. Molecular and cellular ...
The midbrain tegmentum is the part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. Structures included in the midbrain tegmentum include the red nucleus, reticular formation, and substantia nigra. The red nucleus is responsible for controlling basic body and limb movements.
The RMTg plays a "crucial role" in the regulation of dopaminergic neuronal activity in the central nervous system by endogenous opioids and opiate drugs. [1] [2] The GABAergic neurons that project from the RMTg to the midbrain dopaminergic nuclei (i.e., the ventral tegmental area and substantia nigra pars compacta) express μ-opioid receptors.
The midbrain tegmentum is the portion of the midbrain ventral to the cerebral aqueduct, and is much larger in size than the tectum. It communicates with the cerebellum by the superior cerebellar peduncles , which enter at the caudal end, medially, on the ventral side; the cerebellar peduncles are distinctive at the level of the inferior ...
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The periaqueductal gray (PAG), also known as the central gray, is a brain region that plays a critical role in autonomic function, motivated behavior and behavioural responses to threatening stimuli. [1] [2] PAG is also the primary control center for descending pain modulation. It has enkephalin-producing cells that suppress pain.
The medial longitudinal fasciculus (MLF) is a prominent bundle of nerve fibres which pass within the ventral/anterior portion of periaqueductal gray of the mesencephalon (midbrain). [1] It contains the interstitial nucleus of Cajal, responsible for oculomotor control, head posture, and vertical eye movement. [2]