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Myristoylation allows for weak protein–protein and protein–lipid interactions [5] and plays an essential role in membrane targeting, protein–protein interactions and functions widely in a variety of signal transduction pathways.
Protein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions between pairs or groups of proteins. Understanding protein–protein interactions is important for the investigation of intracellular signaling pathways, modelling of protein complex ...
Protein–lipid interaction is the influence of membrane proteins on the lipid physical state or vice versa. The questions which are relevant to understanding of the structure and function of the membrane are: 1) Do intrinsic membrane proteins bind tightly to lipids (see annular lipid shell ), and what is the nature of the layer of lipids ...
Constituent amino-acids can be analyzed to predict secondary, tertiary and quaternary protein structure. This list of protein structure prediction software summarizes notable used software tools in protein structure prediction, including homology modeling, protein threading, ab initio methods, secondary structure prediction, and transmembrane helix and signal peptide prediction.
Average Packing Density [5] 2006 Web Server-AMYLPRED2: Secondary structure-related. Relates average packing density of residues to the formation of amyloid fibrils. sequence - Amyloidogenic regions Beta-strand contiguity [6] 2007 Web Server- AMYLPRED2: Phenomenological. Prediction of B-strand propensity score to locate in the amyloid fibril ...
Accurate prediction of protein function can have longstanding implications on biomedical and pharmaceutical research. The CAFA experiment is designed to provide unbiased assessment of computational methods, to stimulate research in computational function prediction, and provide insights into the overall state-of-the-art in function prediction.
[4] [5] The protein Top7, developed in David Baker's lab, was designed completely using protein design algorithms, to a completely novel fold. [6] More recently, Baker and coworkers developed a series of principles to design ideal globular-protein structures based on protein folding funnels that bridge between secondary structure prediction and ...
Critical Assessment of PRediction of Interactions (CAPRI) is a community-wide experiment in modelling the molecular structure of protein complexes, otherwise known as protein–protein docking. The CAPRI [ 1 ] is an ongoing series of events in which researchers throughout the community attempt to dock the same proteins, as provided by the ...