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Buspirone, sold under the brand name Buspar among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder (GAD). [ 10 ] [ 11 ] It is a serotonin 5-HT 1A receptor partial agonist , increasing action at serotonin receptors in the brain. [ 3 ]
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Buspirone can be useful in GAD but not particularly effective in treating phobias, panic disorder or social anxiety disorders. [2] It is a safer option for long-term use as it does not cause dependence like benzodiazepines. [11]
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Trazodone is a 5-HT 1A receptor partial agonist similarly to buspirone and tandospirone but with comparatively greater intrinsic activity. [ 90 ] [ 107 ] [ 108 ] A range of weak affinities (K i ) have been reported for trazodone at the human histamine H 1 receptor , including 220 nM, [ 90 ] 350 nM, [ 105 ] 500 nM, [ 109 ] and 1,100 nM.
Buspirone was originally classified as an azaspirodecanedione, shortened to azapirone or azaspirone due to the fact that its chemical structure contained this moiety, and other drugs with similar structures were labeled as such as well. However, despite all being called azapirones, not all of them actually contain the azapirodecanedione ...
Buspar – an anxiolytic used to treat generalized anxiety disorder; Belbuca, Buprenex, Butrans, Subutex, Probuohine (buprenorphine) - an opioid medicine used to treat moderate to severe pain, and in some formulations to treat opioid use disorder; Belsomra – used to treat insomnia
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