Search results
Results from the WOW.Com Content Network
Intravascular hemolysis describes hemolysis that happens mainly inside the vasculature. [1] As a result, the contents of the red blood cell are released into the general circulation, leading to hemoglobinemia [ 2 ] and increasing the risk of ensuing hyperbilirubinemia .
A red blood cell in a hypotonic solution, causing water to move into the cell A red blood cell in a hypertonic solution, causing water to move out of the cell. Hemolysis or haemolysis (/ h iː ˈ m ɒ l ɪ s ɪ s /), [1] also known by several other names, is the rupturing of red blood cells (erythrocytes) and the release of their contents into surrounding fluid (e.g. blood plasma).
Acquired hemolytic anemia is also encountered in burns and as a result of certain infections (e.g. malaria). [15] [18] Paroxysmal nocturnal hemoglobinuria (PNH), sometimes referred to as Marchiafava-Micheli syndrome, is a rare, acquired, potentially life-threatening disease of the blood characterized by complement-induced intravascular ...
Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. [1] The condition is caused by excessive intravascular hemolysis, in which large numbers of red blood cells (RBCs) are destroyed, thereby releasing free hemoglobin into the plasma. [2]
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
Hemosiderinuria (syn. haemosiderinuria) is the presence of hemosiderin in urine. [1] It is often the result of chronic intravascular hemolysis, in which hemoglobin is released from red blood cells into the bloodstream in excess of the binding capacity of haptoglobin.
This is an effect of intravascular hemolysis, in which hemoglobin separates from red blood cells, a form of anemia. Hemoglobinemia can be caused by intrinsic or extrinsic factors. When hemoglobinemia is internally caused, it is a result of recessive genetic defects that cause the red blood cells to lyse , letting the hemoglobin spill out of the ...
Paroxysmal cold hemoglobinuria (PCH) or Donath–Landsteiner hemolytic anemia (DLHA) is an autoimmune hemolytic anemia featured by complement-mediated intravascular hemolysis after cold exposure. [1] It can present as an acute non-recurrent postinfectious event in children, or chronic relapsing episodes in adults with hematological malignancies ...