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α-klotho is highly expressed in the brain, liver and kidney. [9] β-klotho is predominantly expressed in the liver. [10] [9] γ-klotho is expressed in the skin. [9] Klotho can exist in a membrane-bound form or a (hormonal) soluble, circulating form. [11] Proteases can convert the membrane-bound form into the circulating form. [12]
Clotho (/ ˈ k l oʊ θ oʊ /; Greek: Κλωθώ) or Klotho, is a mythological figure. She is the youngest goddess of the Three Fates or Moirai. In ancient Greek mythology, she spins the thread of human life, her sisters draw out and cut the thread. She also made major decisions, such as when a person was born, thus in effect controlling people ...
Klotho may refer to Klotho (Greek mythology) or Clotho, one of the Moirai, or Fates, in Greek mythology; 97 Klotho, an asteroid; Klotho (biology), a membrane protein;
FGF21 is the primary endogenous agonist of the FGF21 receptor, which is composed of the co-receptors FGF receptor 1 and β-Klotho. [ 7 ] FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development , cell growth, morphogenesis , tissue repair, tumor ...
The Klotho gene is referred to as the ‘anti-aging gene’ because studies have shown that over-expression of the gene results in improved cognition and a prolonged life span, whereas, conversely, an absence of the gene and gene transcript causes rapid death from age-related pathologies.”
The elevation of Moira to a goddess who determines the course of events appears in the newer parts of the epos. In the Odyssey, she is accompanied by the "Spinners", the personifications of Fate, who do not yet have separate names. [47] In his writing, the poet Hesiod introduces a moral purpose to the Moirai which is absent in the Homeric poems ...
In his Republic, Plato records that Klotho sings of the past, Lachesis of the present, and Atropos of the future. [22] In Roman legend, the Parcae were three goddesses who presided over the births of children and whose names were Nona ("Ninth"), Decuma ("Tenth"), and Morta ("Death"). They too were said to spin destinies, although this may have ...
8074 64654 Ensembl ENSG00000118972 ENSMUSG00000000182 UniProt Q9GZV9 Q9EPC2 RefSeq (mRNA) NM_020638 NM_022657 RefSeq (protein) NP_065689 NP_073148 Location (UCSC) Chr 12: 4.37 – 4.38 Mb Chr 6: 127.05 – 127.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates ...