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PHOTO: Semaglutide (GLP-1) weight-loss drug Wegovy, made by pharmaceutical company Novo Nordisk is seen on Oct. 16, 2024. (James Manning/PA Images via Getty Images)
Phosphite esters are typically prepared by treating phosphorus trichloride with an alcohol. For alkyl alcohols the displaced chloride ion can attack the phosphite, causing dealkylation to give a dialkylphosphite and an organochlorine compound. [1] [2] The overall reaction is as follows: PCl 3 + 3 C 2 H 5 OH → (C 2 H 5 O) 2 P(O)H + 2 HCl + C 2 ...
Diethyl phosphite hydrolyzes to give phosphorous acid. Hydrogen chloride accelerates this conversion.: [2] Diethyl phosphite undergoes transesterification upon treating with an alcohol. For alcohols of high boiling points, the conversion can be driven by removal of ethanol: [8] (C 2 H 5 O) 2 P(O)H + 2 ROH → (RO) 2 P(O)H + 2 C 2 H 5 OH
Various specialised methods have been developed on the laboratory-scale for scientific investigations. These are rarely employed in bulk manufacturing. Examples include the Atherton-Todd reaction, which converts a dialkyl phosphite to a phosphoryl chloride. This can then react with an alcohol to give an organophosphate and HCl.
5. Alcohol Disrupts Your Sleep. Yes, it can feel like a nightcap helps you drift off. But alcohol can disrupt your sleep quite a bit. It can trigger insomnia, obstructive sleep apnea, short sleep ...
Weight-related health considerations unique to young women may also drive them to take GLP-1s. PCOS , which affects 7-10% of women between 18 and 44 in the U.S., including Sipes, is one of them.
Triethyl phosphite (TEP) is an organophosphorus compound, specifically a phosphite ester, with the formula P(OCH 2 CH 3) 3, often abbreviated P(OEt) 3. It is a colorless, malodorous liquid. It is used as a ligand in organometallic chemistry and as a reagent in organic synthesis.
The trial involved 48 people with alcohol-use disorder, which for men means consuming more than 14 drinks a week, with two or more heavy-drinking events during the week; for women, it means ...