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  2. Challenge–dechallenge–rechallenge - Wikipedia

    en.wikipedia.org/wiki/Challenge–dechallenge...

    Peter Breggin asserted that there was an association between fluoxetine (Prozac) use and suicidal thoughts.While his research group were investigating the effectiveness and side effects of the medication, Breggin noticed that only certain individuals responded to the medication with increased thoughts of suicide, and used the challenge–dechallenge–rechallenge protocol in an effort to ...

  3. Polypharmacy - Wikipedia

    en.wikipedia.org/wiki/Polypharmacy

    Poor medical adherence is a common challenge among individuals who have increased pill burden and are subject to polypharmacy. [53] It also increases the possibility of adverse medication reactions (side effects) and drug-drug interactions. High pill burden has also been associated with an increased risk of hospitalization, medication errors ...

  4. Drug therapy problems - Wikipedia

    en.wikipedia.org/wiki/Drug_therapy_problems

    Unnecessary drug therapy. This could occur when the patient has been placed on too many medications for their condition and the drug is simply not needed. [7] Wrong drug. This could occur when a patient is given medication that does not treat the patient's condition. Ex. A heart medication to treat an infection. [7] Dose too low.

  5. Adherence (medicine) - Wikipedia

    en.wikipedia.org/wiki/Adherence_(medicine)

    In medicine, patient compliance (also adherence, capacitance) describes the degree to which a patient correctly follows medical advice.Most commonly, it refers to medication or drug compliance, but it can also apply to other situations such as medical device use, self care, self-directed exercises, or therapy sessions.

  6. Analysis of clinical trials - Wikipedia

    en.wikipedia.org/wiki/Analysis_of_clinical_trials

    This analysis can be restricted to only the participants who fulfill the protocol in terms of the eligibility, adherence to the intervention, and outcome assessment. This analysis is known as an "on-treatment" or "per protocol" analysis. A per-protocol analysis represents a "best-case scenario" to reveal the effect of the drug being studied.

  7. HIV drug resistance - Wikipedia

    en.wikipedia.org/wiki/HIV_drug_resistance

    Proper adherence also greatly reduces the risk of the spread of the virus, thereby improving general public health and lowering health care spending. [12] Some drugs are known to have lower incidences of resistance and may be preferable for individuals known to have difficulty adhering to a drug routine, but these benefits have to be weighed ...

  8. Prescription drug addiction - Wikipedia

    en.wikipedia.org/wiki/Prescription_Drug_Addiction

    Patients who have been prescribed medications to treat a health condition or disorder are shown to be more vulnerable to prescription drug abuse and addiction, especially when the prescribed medicine falls into the same drug classes of common illicit drugs. [20] For example, methylphenidate and amphetamines are in the same stimulant category as ...

  9. Rule of three (statistics) - Wikipedia

    en.wikipedia.org/wiki/Rule_of_three_(statistics)

    When n is greater than 30, this is a good approximation of results from more sensitive tests. For example, a pain-relief drug is tested on 1500 human subjects, and no adverse event is recorded. From the rule of three, it can be concluded with 95% confidence that fewer than 1 person in 500 (or 3/1500) will experience an adverse event.

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