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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
A general lack of energy, fatigue, and tiredness that cannot be otherwise explained is also a symptom of a major depressive episode. [3] A person may feel tired without engaging in any physical activity, which may cause day-to-day tasks, such as showering, to become unmanageable. [10]
Vitamin B 2, B 6 and B 12 deficiency may cause depression in females. [61] A 2025 study suggests that depression affects not only mental health but also accelerates the development of chronic physical conditions. [62] Individuals with a history of depression are at a higher risk of developing long-term health issues, including heart disease and ...
Regular exercise can also enhance cognitive function, alertness, and concentration while preventing fatigue — all of which can be impacted by emotional stress. Any form of movement can help ...
On those days, participants' psychological and physical well-being worsened, with people reporting higher levels of fatigue, sickness, dissatisfaction with life, and depression.
Depression is a major mental-health cause of disease burden. Its consequences further lead to significant burden in public health, including a higher risk of dementia, premature mortality arising from physical disorders, and maternal depression impacts on child growth and development. [69]
Low levels of positive affect in the Tripartite Model characterize depression. [13] [18] Signs of low positive affect include fatigue, loneliness, sadness, and lethargy. [13] Positive affect is important because it is a construct used in order to differentiate depression from anxiety. [1] [20]
[31] [32] Several physical and mental disorders may present with symptoms similar to exhaustion disorder, which makes it a diagnosis of exclusion. [33] Relevant physical alternative diagnoses are symptom dependent, but could include hypothyroidism, vitamin B 12 deficiency, COPD, cardiovascular disease and diabetes. [34]
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