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Neurology. Early-onset Alzheimer's disease ( EOAD ), also called younger-onset Alzheimer's disease ( YOAD ), [ 1] is Alzheimer's disease diagnosed before the age of 65. [ 2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are ...
The mutation is extremely rare – it has only ever been found in two Swedish families and has never been found in the general population in any other countries. The mutation had important consequences for Alzheimer's disease research. The mutation occurs in the gene which encodes amyloid precursor protein (APP), which is proteolysed into beta ...
Alzheimer's disease ( AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2] and is the cause of 60–70% of cases of dementia. [ 2][ 15] The most common early symptom is difficulty in remembering recent events. [ 1] As the disease advances, symptoms can include problems with language, disorientation ...
Neurology. Primary familial brain calcification[ 1] (PFBC), also known as familial idiopathic basal ganglia calcification ( FIBGC) and Fahr's disease, [ 1] is a rare, [ 2] genetically dominant or recessive, inherited neurological disorder characterized by abnormal deposits of calcium in areas of the brain that control movement.
Fatal insomnia is an extremely rare neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. [ 2] The majority of cases are familial ( fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically ( sporadic fatal insomnia [sFI]).
Possible Alzheimer's disease: There is a dementia syndrome with an atypical onset, presentation or progression; and without a known etiology; but no co-morbid diseases capable of producing dementia are believed to be in the origin of it. Unlikely Alzheimer's disease: The patient presents a dementia syndrome with a sudden onset, focal neurologic ...
A neurodegenerative diseaseis caused by the progressive loss of neurons, in the process known as neurodegeneration. [2][3]Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system ...
Brain Aβ is elevated in people with sporadic Alzheimer's disease. Aβ is the main constituent of brain parenchymal and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic. [33] [34] [35] It is unresolved how Aβ accumulates in the central nervous system and subsequently initiates the disease of cells. Significant ...
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