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Individuals with metastatic disease have been treated with chemotherapy (e.g. doxorubicin plus ifosfamide or eribulin) similar to the regimens used for dedifferentiated liposarcoma (see above section on the treatment of this liposarcoma type) [6] About 20% of PLS tumors metastasize to distant sites, the most common of which are lung (82% of ...
Desmoplastic small-round-cell tumor (DSRCT) is an aggressive and rare cancer that primarily occurs as masses in the abdomen. [4] Other areas affected may include the lymph nodes, the lining of the abdomen, diaphragm, spleen, liver, chest wall, skull, spinal cord, large intestine, small intestine, bladder, brain, lungs, testicles, ovaries, and the pelvis.
Occasionally medical imaging or tissue biopsy is used to confirm the diagnosis. [1] Treatment is typically by observation or surgical removal. [1] Rarely, the condition may recur following removal, but this can generally be managed with repeat surgery. [1] They are not generally associated with a future risk of cancer. [1]
A sarcoma is a malignant tumor, a type of cancer that arises from cells of mesenchymal (connective tissue) origin. [1] [2] Connective tissue is a broad term that includes bone, cartilage, muscle, fat, vascular, or other structural tissues, and sarcomas can arise in any of these types of tissues.
Survival rates for most childhood cancers have improved, with a notable improvement in acute lymphoblastic leukemia (the most common childhood cancer). Due to improved treatment, the 5-year survival rate for acute lymphoblastic leukemia has increased from less than 10% in the 1960s to about 90% during the time period 2003-2009. [16]
Randall has advanced sarcoma research and treatment. [2] His career spans roles at institutions such as the Yale School of Medicine, University of California, San Francisco (UCSF), University of Washington/Fred Hutchinson Cancer Center, University of Utah’s Huntsman Cancer Institute, Primary Children's Hospital, and Shriners Hospitals for ...
Kaposi sarcoma, a rare cancer of the cells that line blood vessels in the skin and mucous membranes, is caused by human herpesvirus 8. Kaposi sarcoma often occurs in patients with acquired immune deficiency syndrome. Kaposi sarcoma, however, has different characteristics from typical soft-tissue sarcomas and is treated differently. [8]
As of the 2010s, there is a "clear consensus" [2] from medical groups, including the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group and the European Society for Medical Oncology: immediate surgical resection is no longer the first-line treatment, particularly in asymptomatic patients.