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Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
High-pressure nervous syndrome (HPNS – also known as high-pressure neurological syndrome) is a neurological and physiological diving disorder which can result when a diver descends below about 500 feet (150 m) using a breathing gas containing helium.
Placed immediately after the discharge of a pump that is started fast into a pipe full of a long column of liquid. Reduces start up surge pressure. Placed immediately after a pump, which when caused to stop suddenly, enables a vacuum to form, which pulls the flow back towards the pump. Prevents an implosion bang. Variations on the design include
Hepsin is a cell surface serine protease. [6]Hepson contains a peptidase S1 domain and an SRCR domain. The SRCR domain is located in the extracellular part of the protein, it is formed primarily by three elements of regular secondary structure: a 12-residue alpha helix, a twisted five-stranded antiparallel beta sheet, and a second, two-stranded, antiparallel sheet.
Diffuse proliferative glomerulonephritis (DPGN) is a type of glomerulonephritis that is the most serious form of renal lesions in SLE and is also the most common, occurring in 35% to 60% of patients. [1] In absence of SLE, DPGN pathology looks more like Membranoproliferative glomerulonephritis [citation needed]
On gross pathology, nephrosclerosis manifests as a fine granular surface. [4]"Hypertensive" refers to high blood pressure and "nephropathy" means damage to the kidney; hence this condition is where chronic high blood pressure causes damages to kidney tissue; this includes the small blood vessels, glomeruli, kidney tubules and interstitial tissues.
Human placental lactogen (hPL), also called human chorionic somatomammotropin (hCS) or human chorionic somatotropin, is a polypeptide placental hormone, the human form of placental lactogen (chorionic somatomammotropin). Its structure and function are similar to those of human growth hormone.
After cyclization, hopanoids are frequently modified by hopanoid biosynthesis enzymes encoded by genes in the same operon as shc, hpn. [29] For instance, the radical SAM protein HpnH adds an adenosine group to diploptene, forming the extended C 35 hopanoid adenosylhopane, which can then be further functionalized by other hpn gene products. [30]