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David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.
Lifespan debuted at #11 on The New York Times hardcover nonfiction bestseller list on September 28, 2019. [1]The book received mixed reviews from critics. "If you're even mildly hopeful about dunking a basketball at the age of 50, or hiking the Appalachian Trail at 70, or blowing 100 candles out on your birthday cake someday, you might consider making room for Lifespan on your bookshelf," one ...
Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...
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In 1993, Cynthia Kenyon's lab at UCSF discovered that a single-gene mutation in could double the lifespan of C. elegans. That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging by activation of sirtuins. [8]
The median "ideal lifespan" was 91 years of age and the majority of the public (63%) viewed medical advances aimed at prolonging life as generally good. 41% of Americans believed that radical life extension (RLE) would be good for society, while 51% said they believed it would be bad for society. [91]
In 1993, Kenyon's discovery that a single-gene mutation could double the lifespan of C. elegans and that this could be reversed by a second mutation in daf-16m, [4] sparked an intensive study of the molecular biology of aging, including work by Leonard Guarente and David Sinclair. [1]
David Sinclair and Rachel Drake shattered records in winning the men's and women's titles in the 62nd annual JFK 50 Mile ultramarathon on Saturday. Sinclair, 32, of South Burlington, Vermont, took ...
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