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The orange trend-line shows that by 2020 online prediction servers had been able to learn from and match this performance, while the best other groups (green curve) had on average been able to make some improvements on it. However, the black trend curve shows the degree to which AlphaFold 2 had surpassed this again in 2020, across the board.
The pair were recognized for their work on protein-structure prediction. In 2020, DeepMind developed an AI tool to predict protein structures called AlphaFold2.
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Interpretation of PAE values allows scientists to understand the level of confidence in the predicted structure of a protein: Lower PAE values between residue pairs from different domains indicate that the model predicts well-defined relative positions and orientations for those domains.
In May 2024, Jumper’s team unveiled AlphaFold 3, which in addition to proteins, can predict other molecules like DNA and RNA. Unlike its predecessor, AlphaFold 3 was not made open source.
A prediction game is a game which allow users to guess at the outcome of future events. Prediction games are generally operated online and are free for users to play. Points are awarded to players who most accurately predict the outcome of an event, and those points are converted into cash prizes.
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Prof. David Baker, a protein research scientist at the University of Washington, founded the Foldit project.Seth Cooper was the lead game designer. Before starting the project, Baker and his laboratory coworkers relied on another research project named Rosetta [5] to predict the native structures of various proteins using special computer protein structure prediction algorithms.