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The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. [1] The pancreatic islets constitute 1–2% of the pancreas volume and receive 10–15% of its blood flow. [2] [3] The pancreatic islets are ...
At first, there was a lot of controversy about what the Islets were made of and what they did. [3] It appeared that all of the cells were the same within the Islet, but were histologically distinct from acini cells. [3] Laguesse discovered that the cells within the Islets of Langerhans contained granules that distinguished them from acini cells ...
Epsilon cells (ε-cells) are one of the five types of endocrine cells found in regions of the pancreas called Islets of Langerhans. [1] Epsilon cells produce the hormone ghrelin that induces hunger. They were first discovered in mice. In humans, these cells compose less than 1% of all islet cells.
Beta cells (β-cells) are specialized endocrine cells located within the pancreatic islets of Langerhans responsible for the production and release of insulin and amylin. [1] Constituting ~50–70% of cells in human islets, beta cells play a vital role in maintaining blood glucose levels. [2] Problems with beta cells can lead to disorders such ...
Pancreatic polypeptide cells (PP cells), or formerly as gamma cells (γ-cells), or F cells, are cells in the pancreatic islets (Islets of Langerhans) of the pancreas.Their main role is to help synthesize and regulate the release of pancreatic polypeptide (PP), after which they have been named.
Paul Langerhans (25 July 1847 – 20 July 1888) was a German pathologist, physiologist and biologist, credited with the discovery of the cells that secrete insulin, named after him as the islets of Langerhans.
The mesoderm gives rise to myeloid progenitor cells, which further differentiate into macrophage populations. [2] As opposed to macrophages in the islet stroma (tissue), whose developmental origin is from the yolk sac (primitive hematopoiesis), islet resident progenitors come from hematopoietic stem cells (HSCs) of the definitive hematopoiesis.
Islet transplantation is the transplantation of isolated islets from a donor pancreas into another person. It is a treatment for type 1 diabetes. [1] Once transplanted, the islets begin to produce insulin, actively regulating the level of glucose in the blood. Islets are usually infused into the person's liver. [2]