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The first line treatment for narcolepsy, modafinil, has been found to interact indirectly with the orexin system. It is also likely that an orexin receptor agonist will be found and developed for the treatment of hypersomnia. [ 84 ]
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
Pitolisant is the first eugeroic drug that acts by blocking the histamine H 3 autoreceptor, which increases the activity of histamine neurons in the brain. Pitolisant has been shown to be effective and well-tolerated for the treatment of narcolepsy with or without cataplexy. [19] [20] [21]
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Firazorexton (INN Tooltip International Nonproprietary Name; development code TAK-994) is an experimental orexin 2 (OX 2) receptor agonist first described in a 2019 patent filed by Takeda Pharmaceutical Company. [1] [2] Firazorexton was studied by Takeda for the treatment of narcolepsy.
Colchicine (Colcrys) for pericarditis: colchicine is indicated for the treatment and prevention of gout, though it is also generally considered first-line treatment for acute pericarditis, as well as preventing recurrent episodes. Although the exact mechanism of colchicine is not fully understood, its anti-inflammatory effect for pericarditis ...
Amphetamines are a drug used to commonly treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Past studies link amphetamine use to possibly developing the psychiatric disorder ...
Although stimulants are the first-line treatment for ADHD symptoms, second-line treatments like Wellbutrin may be more appropriate for some people. dragana991/istockphoto Side Effects
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