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Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ 5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA).
Aldosterone stimulates Na + and water reabsorption from the gut, salivary and sweat glands in exchange for K +. Aldosterone stimulates secretion of H + via the H+/ATPase in the intercalated cells of the cortical collecting tubules; Aldosterone upregulates expression of NCC in the distal convoluted tubule chronically and its activity acutely. [18]
Androsterone is also known to be an inhibitory androstane neurosteroid, [5] [6] acting as a positive allosteric modulator of the GABA A receptor, [7] and possesses anticonvulsant effects. [8] The unnatural enantiomer of androsterone is more potent as a positive allosteric modulator of GABA A receptors and as an anticonvulsant than the natural ...
Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Eplerenone, sold under the brand name Inspra, is an aldosterone antagonist type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for people with resistant hypertension due to elevated aldosterone.
[3] 3β-Androstanediol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ. [4] [5] It has approximately 3% and 7% of the affinity of estradiol at the ERα and ERβ, respectively. [6] Unlike 3α-androstanediol, 3β-androstanediol does not bind to the GABA A receptor. [7]
Tablet: 30–200 mg/day Fluoxymesterone: Tablet: 10–40 mg 3x/day Calusterone: Tablet: 40–80 mg 4x/day Normethandrone: Tablet: 40 mg/day Buccal: Methyltestosterone: Tablet: 25–100 mg/day Injection (IM Tooltip intramuscular injection or SC Tooltip subcutaneous injection) Testosterone propionate: Oil solution: 50–100 mg 3x/week ...