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Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968. [3] Clobazam was first synthesized in 1966 and first published in 1969. Clobazam was originally marketed as an anxioselective anxiolytic since 1970, [ 4 ] [ 5 ] and an anticonvulsant since 1984. [ 6 ]
[93] [26] [94] [95] [96] Oral ethinylestradiol at 10 μg/day has been found to have about 1.5- to 2.5-fold the impact of 2 mg/day oral estradiol valerate on HDL cholesterol and triglycerides. [ 97 ] [ 98 ] [ 99 ] The influence of 20 or 50 μg/day oral ethinylestradiol on coagulation factors and HDL cholesterol is markedly greater than that of 2 ...
[3] [12] This is true for oral doses of 2 mg and 4 mg, but absorption was found to be incomplete for an oral dose of 8 mg. [3] [60] This dose showed 76% of the expected bioavailability based on dose proportionality and area-under-the-curve levels, indicating a small deviation from linearity.
Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Though temsirolimus shows activity on its own, it is also known to be converted to sirolimus (rapamycin) in vivo; [4] therefore, its activity may be more attributed to its metabolite rather than the prodrug itself (despite claims to the ...
Rasagiline inhibits platelet MAO-B activity with single doses by 35% one-hour after 1 mg, 55% after 2 mg, 79% after 5 mg, and 99% after 10 mg in healthy young people. [ 1 ] [ 55 ] [ 2 ] [ 54 ] With all dose levels, maximum inhibition is maintained for at least 48 hours after the dose.
The pharmacokinetics of dienogest are linear; single oral doses of dienogest were found to result in maximal levels of 28 ng/mL with 1 mg, 54 ng/mL with 2 mg, 101 ng/mL with 4 mg, and 212 ng/mL with 8 mg. [7] The corresponding area-under-the-curve levels were 306, 577, 1153, and 2293 ng/mL, respectively. [7]
Liraglutide, sold under the brand name Victoza among others, is an anti-diabetic medication used to treat type 2 diabetes, and chronic obesity. [6] [7] It is a second-line therapy for diabetes following first-line therapy with metformin. [6] [8] Its effects on long-term health outcomes like heart disease and life expectancy are unclear.
Thiamazole, also known as methimazole, is a medication used to treat hyperthyroidism. [2] This includes Graves disease, toxic multinodular goiter, and thyrotoxic crisis. [2] It is taken by mouth. [2] Full effects may take a few weeks to occur. [3] Common side effects include itchiness, hair loss, nausea, muscle pain, swelling, and abdominal ...