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A dermatofibroma is associated with the dimple sign; by applying lateral pressure, there is a central depression of the dermatofibroma. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Dermatofibromas can be found anywhere on the body, but most often they are found on the legs and arms. [5]
Dermatofibrosarcoma protuberans (DFSP) [2] is a rare locally aggressive malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells in the middle layer of the skin (dermis). [3] Estimates of the overall occurrence of DFSP in the United States are 0.8 to 4.5 cases per million persons per year.
About 10 [13] to 15% [1] of individuals initially or subsequently present with metastases, [2] most commonly in the lung, less commonly in the regional lymph nodes draining the site of the primary dermal tumor, [13] or, rarely, in the liver, kidney, soft tissue sites outside of the primary dermal tumor's areas, [3] mediastinum, or brain.
The hard fibroma (fibroma durum) consists of many fibres and few cells, e.g. in skin it is called dermatofibroma (fibroma simplex or nodulus cutaneous). [2] A special form is the keloid, which derives from hyperplastic growth of scars.
The term fibromatosis refers to a group of soft tissue tumors [1] which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence.
However, a benign tumor is not benign in the usual sense; the name merely specifies that it is not "malignant", i.e. cancerous. While benign tumors usually do not pose a serious health risk, they can be harmful or fatal. [2] Many types of benign tumors have the potential to become cancerous through a process known as tumor progression. For this ...
Prostate cancer: 1.5 million. Stomach cancer: 970,000. While lung cancer diagnoses slightly surpassed those of breast cancer in 2022, breast cancer remained the most common cause of cancer when ...
2 References. Toggle the table of contents. ... Epithelioid cell histiocytoma is a rare skin condition that is considered to be a variant of a dermatofibroma. [1]