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The extreme endpoint of this distribution are the so-called 'monogenic' obesities where most of the impact on body weight can be tied to a mutation in a single gene that runs in a single family. The classic example of such a genetic effect is the presence of mutations in the leptin gene. [29]
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors.
People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships. [1] [2] Nutritional genomics or Nutrigenomics is the relation between food and inherited genes, it was first expressed in 2001. [3] [4]
The research team at Mayo Clinic developed a test called MyPhenome that categorizes the type of obesity phenotype that can help improve weight loss. The four types were: The four types were:
During the 20th century, as populations reached their genetic potential for height, weight began increasing much more than height, resulting in obesity. [115] In the 1950s, increasing wealth in the developed world decreased child mortality, but as body weight increased, heart and kidney disease became more common.
SMN1 is the telomeric copy of the gene encoding the SMN protein; the centromeric copy is termed SMN2. SMN1 and SMN2 are part of a 500 kbp inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of ...
In biology, a gene cassette is a type of mobile genetic element that contains a gene and a recombination site. Each cassette usually contains a single gene and tends to be very small; on the order of 500–1,000 base pairs. They may exist incorporated into an integron or freely as circular DNA. [1]
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related to: mattress carrying that weight gain is called a single gene