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Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.
[1] [4] [2] It is a tissue factor pathway inhibitor (TFPI) antagonist. [4] It was developed by Pfizer. [5] Marstacimab is a new type of medication that, rather than replacing a clotting factor, works by reducing the amount, and therefore, the activity of, the naturally occurring anticoagulation protein called tissue factor pathway inhibitor. [4]
21789 Ensembl ENSG00000105825 ENSMUSG00000029664 UniProt P48307 O35536 RefSeq (mRNA) NM_006528 NM_001271003 NM_001271004 NM_009364 NM_001381907 NM_001381908 RefSeq (protein) NP_001257932 NP_001257933 NP_006519 NP_033390 NP_001368836 NP_001368837 Location (UCSC) Chr 7: 93.89 – 93.89 Mb Chr 6: 3.96 – 3.99 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tissue factor pathway ...
The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [5] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus, a species of poxvirus. They are short (about 50 to 60 ...
This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. Semaglutide — the active ingredient in the brand-name meds Ozempic, Wegovy, and Rybelsus — treats type 2 diabetes and obesity ...
tissue factor pathway inhibitor (TFPI) Y: bleeding with hemophilia: Maslimomab: mouse: T-cell receptor: Mavrilimumab [38] mab: human: GMCSF receptor α-chain: rheumatoid arthritis: Matuzumab [24] mab: humanized: Epidermal growth factor receptor (EGFR) colorectal, lung and stomach cancer Mepolizumab [47] Bosatria: mab: humanized: IL-5: Y: asthma ...
Meet the expert: Steven K. Malin, PhD, is an associate professor in the Department of Kinesiology and Health at Rutgers Robert Wood Johnson Medical School; Scott Kaiser, MD, is a geriatrician and ...
[5] [8] It is an anti-tissue factor pathway inhibitor. [5] [8] The most common adverse reactions include injection site reactions and hives (urticaria). [11] Concizumab was approved for medical use in Canada in March 2023, [4] [12] in Australia in July 2023, [1] in the European Union in December 2024, [9] and the United States in December 2024 ...