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  2. Dantrolene - Wikipedia

    en.wikipedia.org/wiki/Dantrolene

    Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]

  3. Muscle relaxant - Wikipedia

    en.wikipedia.org/wiki/Muscle_relaxant

    Dantrolene, although thought of primarily as a peripherally acting agent, is associated with CNS effects, whereas baclofen activity is strictly associated with the CNS. Muscle relaxants are thought to be useful in painful disorders based on the theory that pain induces spasm and spasm causes pain.

  4. Hypertonia - Wikipedia

    en.wikipedia.org/wiki/Hypertonia

    Baclofen, diazepam and dantrolene remain the three most commonly used pharmacologic agents in the treatment of spastic hypertonia. Baclofen is generally the drug of choice for spinal cord types of spasticity, while sodium dantrolene is the only agent which acts directly on muscle tissue. Tizanidine is also available.

  5. Antispasmodic - Wikipedia

    en.wikipedia.org/wiki/Antispasmodic

    Applicable conditions include acute back [8] or neck pain, or pain after an injury. Long-term use of muscle relaxants in such cases is poorly supported. [8] Spasm may also be seen in movement disorders featuring spasticity in neurologic conditions such as cerebral palsy, multiple sclerosis, and spinal cord disease. Medications are commonly used ...

  6. Spasticity - Wikipedia

    en.wikipedia.org/wiki/Spasticity

    Spasticity is found in conditions where the brain and/or spinal cord are damaged or fail to develop normally; these include cerebral palsy, multiple sclerosis, spinal cord injury and acquired brain injury including stroke. Damage to the CNS as a result of stroke or spinal cord injury, alter the [net inhibition] of peripheral nerves in the ...

  7. The best non-alcoholic drinks to try during Dry January

    www.aol.com/lifestyle/best-non-alcoholic-drinks...

    NON takes non-alcoholic wine to a new level with its innovative blends and rich, complex flavors. The brand’s wines are made with natural ingredients like fruits, spices, and botanicals ...

  8. Sandra Bullock Details 'Deep Concern' for Fans in Urgent Warning

    www.aol.com/lifestyle/sandra-bullock-details...

    The actress is the latest Hollywood star to issue a similar PSA to fans.

  9. Upper motor neuron syndrome - Wikipedia

    en.wikipedia.org/wiki/Upper_motor_neuron_syndrome

    exaggerated deep tendon reflexes including spasticity, and clonus (a series of involuntary rapid muscle contractions) Such signs are collectively termed the "upper motor neuron syndrome". Affected muscles typically show multiple signs, with severity depending on the degree of damage and other factors that influence motor control. In ...

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