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Early-onset Alzheimer's disease (EOAD), also called younger-onset Alzheimer's disease (YOAD), [1] is Alzheimer's disease diagnosed before the age of 65. [2] It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases.
When the disease is caused by autosomal dominant variants, it is known as early onset familial Alzheimer's disease, which is rarer and has a faster rate of progression. [17] Less than 5% of sporadic Alzheimer's disease have an earlier onset, [17] and early-onset Alzheimer's is about 90% heritable.
Early onset dementia is less common than late onset dementia, the former accounting for approximately 10% of dementias globally. [3] Recent studies estimate the prevalence of early onset dementia to be approximately 3.55 million people aged 30–64 worldwide, and will triple by 2050. [6] with an incidence of 119 per 100,000 individuals. [1]
One genetic variant associated with Alzheimer’s disease progression is presenilin 2 (PSEN2), which is correlated to an increased risk for early-onset familial Alzheimer’s disease (EOFAD ...
“Alzheimer’s disease has a long pre-symptomatic period; Alzheimer’s-related changes take place in the brain 10, 15, even 20 years before the onset of memory and thinking symptoms.
At age 55, the lifetime risk of dementia—up to age 95—was 42%. This risk remained low from ages 55 to 75 (about 4%) but dramatically increased after age 75. Women had a higher lifetime risk of ...
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