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The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. [1] The epidermis layer provides a barrier to infection from environmental pathogens [2] and regulates the amount of water released from the body into the atmosphere through transepidermal water loss. [3]
The dermis is the layer of skin beneath the epidermis that consists of connective tissue and cushions the body from stress and strain. The dermis is tightly connected to the epidermis by a basement membrane. It also harbours many nerve endings that provide the sense of touch and heat.
The dermis is composed of three major types of cells: [3] fibroblasts, macrophages, and mast cells.. Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular gel-like substance primarily composed of glycosaminoglycans (most notably hyaluronan ...
The skin (integument) is a composite organ, made up of at least two major layers of tissue: the epidermis and the dermis. [2] The epidermis is the outermost layer, providing the initial barrier to the external environment. It is separated from the dermis by the basement membrane (basal lamina and reticular lamina). The epidermis contains ...
The dermis is the layer of skin beneath the epidermis that consists of connective tissue and cushions the body from stress and strain. The dermis provides tensile strength and elasticity to the skin through an extracellular matrix composed of collagen fibrils , microfibrils , and elastic fibers , embedded in hyaluronan and proteoglycans . [ 15 ]
Within the healed epidermis they will be replaced by keratinocytes originating from the epidermis. [29] [30] At the opposite, epidermal keratinocytes, can contribute to de novo hair follicle formation during the healing of large wounds. [31] Functional keratinocytes are needed for tympanic perforation healing. [32]
The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the papillary dermis and the reticular dermis. [10] The superficial papillary dermis interdigitates with the overlying rete ridges of the epidermis, between which the two layers interact through the basement membrane zone. [10]
They are present in all layers of the epidermis and are most prominent in the stratum spinosum. [4] They also occur in the papillary dermis , particularly around blood vessels, [ 4 ] as well as in the mucosa of the mouth , foreskin , and vaginal epithelium . [ 5 ]