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Thyroid hormone uptake (T uptake or T 3 uptake) is a measure of the unbound thyroxine binding globulins in the blood, that is, the TBG that is unsaturated with thyroid hormone. [2] Unsaturated TBG increases with decreased levels of thyroid hormones. It is not directly related to triiodothyronine, despite the name T 3 uptake. [2] Reference ranges:
This will lead to an increased thyroid hormone binding ratio. In patients with hypothyroidism, there will be more free binding sites on TBG (due to the decreased amount of circulating T3 / T4) and as such the THBR will be decreased. In general, High with High thyroid activity and Low with Low thyroid activity.
The patient swallows a radioisotope of iodine in the form of capsule or fluid, and the absorption (uptake) of this radiotracer by the thyroid is studied after 4–6 hours and after 24 hours with the aid of a scintillation counter. The dose is typically 0.15–0.37 MBq (4–10 μCi) of 131 I iodide, or 3.7–7.4 MBq (100–200 μCi) of 123 I ...
The Thyrotroph Thyroid Hormone Sensitivity Index (abbreviated TTSI, also referred to as Thyrotroph T4 Resistance Index or TT4RI) is a calculated structure parameter of thyroid homeostasis. It was originally developed to deliver a method for fast screening for resistance to thyroid hormone .
Thyroxine-binding globulin (TBG) is a globulin protein encoded by the SERPINA7 gene in humans. TBG binds thyroid hormones in circulation.It is one of three transport proteins (along with transthyretin and serum albumin) responsible for carrying the thyroid hormones thyroxine (T 4) and triiodothyronine (T 3) in the bloodstream.
A thyroid scan producing images is typically conducted in connection with the uptake test to allow visual examination of the over-functioning gland. [ 11 ] Thyroid scintigraphy is a useful test to characterize (distinguish between causes of) hyperthyroidism, and this entity from thyroiditis.
T 3 is the more metabolically active hormone produced from T 4.T 4 is deiodinated by three deiodinase enzymes to produce the more-active triiodothyronine: . Type I present in liver, kidney, thyroid, and (to a lesser extent) pituitary; it accounts for 80% of the deiodination of T 4.
Thyroid scan uptake increases throughout the recovery phase due to the thyroid gland's enhanced capacity to trap iodine, which eventually returns to normal after full recovery. [7] Thyroid gland enlargement and a region of hypoechogenicity that correlates to the inflammatory area are typically seen on thyroid ultrasonography. [24]