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2. Discovery and development of triptans - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Sumatriptan [4] binds to 5-HT 1D receptors, zolmitriptan, [5] rizatriptan, [6] naratriptan, [7] almotriptan, [8] and frovatriptan [9] binds to 5-HT 1B/1D and eletriptan [10] binds to 5-HT 1B/1D/1F receptors. Triptans are believed to exert their effects through vasoconstriction, leading to reduced carotid arterial circulation without affecting ...

3. Frovatriptan - Wikipedia

   en.wikipedia.org/wiki/Frovatriptan

   Frovatriptan, sold under the brand name Frova, is a triptan drug developed by Vernalis for the treatment of migraine headaches [1] and for short term prevention of menstrual migraine. [2] The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.

4. Triptan - Wikipedia

   en.wikipedia.org/wiki/Triptan

   In spite of expert opinion and evidence to the contrary, the FDA and some other drug governance bodies have stated that monoamine oxidase inhibitors are contraindicated for sumatriptan, zolmitriptan and rizatriptan, [21] [22] and combination with ergot alkaloids such as ergotamine for all substances. [10]

5. Serotonin receptor agonist - Wikipedia

   en.wikipedia.org/wiki/Serotonin_receptor_agonist

   In addition to being 5-HT 1B agonists, triptans (i.e. sumatriptan, almotriptan, zolmitriptan, naratriptan, eletriptan, frovatriptan and rizatriptan) are also agonists at the 5-HT 1D receptor, which contributes to their antimigraine effect caused by vasoconstriction of blood vessels in the brain. The same is true for ergotamine.

6. Antimigraine drug - Wikipedia

   en.wikipedia.org/wiki/Antimigraine_drug

   The triptan drug class includes 1st generation sumatriptan (which has poor bioavailability), and second generation zolmitriptan. [2] Due to their safety, efficacy and selectivity, triptans are considered first line agents for abortion of migraines. [2]

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9. Zolmitriptan - Wikipedia

   en.wikipedia.org/wiki/Zolmitriptan

   Zolmitriptan, sold under the brand name Zomig among others, is a serotonergic medication which is used in the acute treatment of migraine attacks with or without aura and cluster headaches. [3] It is taken by mouth as a swallowed or disintegrating tablet or as a nasal spray .