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For people eating a gluten-free diet who are unable to perform an oral gluten challenge, an alternative to identify a possible celiac disease is an in vitro gliadin challenge of small bowel biopsies, but this test is available only at selected specialized tertiary-care centers.
These procedures are capable of detecting wheat or multiple cereals at concentrations as low as 1 part per million (PPM or 1 mg/kg). A new barley-sensitive ELISA called the R5 sandwich assay does not detect gluten in any of 25 pure oat varieties, but it does detect barley, wheat and rye. [15]
There is a growing body of evidence that the gluten-sensitive intestine differs from the normal gut, several gluten peptides can enter behind the brush border membrane cells. For example, a "33mer" of α-2 gliadin is a magnitude larger than the size exclusion of the tight junction, ω-5 gliadin peptides have been found in the blood stream of ...
Nima delivers a binary result for the sample tested for gluten and peanut. The gluten sensor is tuned to 20 parts per million for gluten and 10 parts per million for peanut. If the sample contains 20 ppm or more of gluten, Nima is designed to deliver a gluten found indication, to indicate gluten was found.
Gluten-related disorders is the term for the diseases triggered by gluten, including celiac disease (CD), non-celiac gluten sensitivity (NCGS), gluten ataxia, dermatitis herpetiformis (DH) and wheat allergy.
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Non-celiac gluten sensitivity (NCGS) or gluten sensitivity [14] is a controversial disorder which can cause both gastrointestinal and other problems. NCGS is included in the spectrum of gluten-related disorders. [3] [4] The definition and diagnostic criteria of non-celiac gluten sensitivity were debated and established by three consensus ...
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