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Antiplatelet drugs effect may be affected by patient's medications, current medical conditions, food and supplements taken. Antiplatelet drugs effect may be increased or decreased. An increase in antiplatelet effect would increase the risk of bleeding and could cause prolonged or excessive bleeding.
Platelet transfusions came into medical use in the 1950s and 1960s. [1] [5] It is on the World Health Organization's List of Essential Medicines. [6] [7] Some versions of platelets have had the white blood cells partially removed or been gamma irradiated which have specific benefits for certain populations. [8]
Activation of platelets and the subsequent aggregation of platelets has a crucial role maintaining normal haemostasis. Disturbance in this system can lead to cerebrovascular, cardiovascular and peripheral vascular diseases where it can lead to a stroke, unstable angina and myocardial infarction. When a vessel is damaged ADP is released from ...
Aside from the procedure, donating platelets is different from donating blood in a few ways. Firstly, the donor must not take aspirin or other anti-platelet medications such as clopidogrel (Plavix) for anywhere from 36 to 72 hours prior to donation (guidelines vary by blood center). (Aspirin can prevent platelets from adhering to clot bleeding.)
Different antithrombotics affect different blood clotting processes: Antiplatelet drugs limit the migration or aggregation of platelets. Anticoagulants limit the ability of the blood to clot. Thrombolytic drugs act to dissolve clots after they have formed.
Platelets are involved in blood clotting, preventing the body from bleeding. Before these components were known, doctors believed that blood was homogeneous. Because of this scientific misunderstanding, many patients died because of incompatible blood transferred to them.
A blood donation occurs when a person voluntarily has blood drawn and used for transfusions and/or made into biopharmaceutical medications by a process called fractionation (separation of whole blood components). A donation may be of whole blood, or of specific components directly .
Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). [10]