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The diagnosis of vancomycin-resistant Staphylococcus aureus (VRSA) is performed by performing susceptibility testing on a single S. aureus isolate to vancomycin. This is accomplished by first assessing the isolate's minimum inhibitory concentration (MIC) using standard laboratory methods, including disc diffusion, gradient strip diffusion, and automated antimicrobial susceptibility testing ...
MRSA can be eradicated with a regimen of linezolid, [87] though treatment protocols vary and serum levels of antibiotics vary widely from person to person and may affect outcomes. [88] The effective treatment of MRSA with linezolid has been successful [87] in 87% of people. Linezolid is more effective in soft tissue infections than vancomycin.
Infections caused by ionizing radiation can be endogenous, originating from the oral and gastrointestinal bacterial flora, and exogenous, originating from breached skin following trauma. The organisms causing endogenous infections are generally gram negative bacilli such as Enterobacteriaceae (i.e. Escherichia coli , Klebsiella pneumoniae ...
Skin and skin structure infections (SSSIs), also referred to as skin and soft tissue infections (SSTIs), [1] or acute bacterial skin and skin structure infections (ABSSSIs), [2] are infections of skin and associated soft tissues (such as loose connective tissue and mucous membranes).
Design of engineered live bacterial therapeutics [1]. Bacterial therapy is the therapeutic use of bacteria to treat diseases.Bacterial therapeutics are living medicines, and may be wild type bacteria (often in the form of probiotics) or bacteria that have been genetically engineered to possess therapeutic properties that is injected into a patient.
Bacterial skin infections include: Impetigo is a highly contagious bacterial skin infection commonly seen in children. [17] It is caused by Staphylococcus aureus, and Streptococcus pyogenes. [18] Erysipelas is an acute streptococcus bacterial infection [19] of the deeper skin layers that spreads via with lymphatic system.
Phages can be bioengineered to target multidrug-resistant bacterial infections, and their use involves the added benefit of preventing the elimination of beneficial bacteria in the human body. [31] Phages destroy bacterial cell walls and membrane through the use of lytic proteins which kill bacteria by making many holes from the inside out. [ 272 ]
The lipoglycopeptide dalbavancin and the oxazolidinone tedizolid has also been approved for use for the treatment of acute bacterial skin and skin structure infection. The first in a new class of narrow-spectrum macrocyclic antibiotics, fidaxomicin, has been approved for the treatment of C. difficile colitis. [162]