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Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. [6] It is primarily used to treat psychotic disorders such as schizophrenia . [ 6 ]
ECG changes [Note 4]; Contact dermatitis; Sensitivity to light; Urticaria (hives); Maculopapular rash; Petechia or edema; Hyperprolactinaemia [Note 5]; Impaired thermoregulation [Note 6] ...
Simone Courvoisier was a French experimental pharmacologist who, while the head of pharmacology at Rhône-Poulenc in the 1950s, investigated the use of the antipsychotic medication chlorpromazine. [ 1 ] [ 2 ] She discovered that the compound promazine had sedating properties despite not being an antihistamine like its precursor promethazine ...
A related concept to D2 potency is the concept of "chlorpromazine equivalence", which provides a measure of the relative effectiveness of antipsychotics. [ 13 ] [ 14 ] The measure specifies the amount (mass) in milligrams of a given drug that must be administered in order to achieve desired effects equivalent to those of 100 milligrams of ...
Jean Delay (14 November 1907, Bayonne – 29 May 1987, Paris) was a French psychiatrist, neurologist, writer, and a member of the Académie française (Chair 17).. His assistant Pierre Deniker conducted a test of chlorpromazine on the male mental ward where Delay worked, and the two published their findings (quickly, with what has been called academic gamesmanship) in 1952. [1]
Promazine (brand name Sparine among others), [2] is used as a short-term add-on treatment for psychomotor agitation. [3] [4] Its approved uses in people is limited, but is used as a tranquilizer in veterinary medicine. [3]
Prochlorperazine is analogous to chlorpromazine; both of these agents antagonize dopaminergic D 2 receptors in various pathways of the central nervous system. This D 2 blockade results in antipsychotic, antiemetic and other effects.
The Vietnamese Wikipedia initially went online in November 2002, with a front page and an article about the Internet Society.The project received little attention and did not begin to receive significant contributions until it was "restarted" in October 2003 [3] and the newer, Unicode-capable MediaWiki software was installed soon after.