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Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. [1]
[8] [9] Patients present with a broad range of symptoms related to severe hypoestrogenism (including cardiovascular and skeletal irregularities [10] [3] [11] [12] [8] [13]) as well as hypercortisolemia, low serum insulin levels, low serum insulin-like growth factor 1 , and low total triiodothyronine (T3). [3]
The most common reason for high serum FSH concentration is in a female who is undergoing or has recently undergone menopause. High levels of FSH indicate that the normal restricting feedback from the gonad is absent, leading to an unrestricted pituitary FSH production. FSH may contribute to postmenopausal osteoporosis and cardiovascular disease ...
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The diagnosis is based on age less than forty, amenorrhea, and two elevated serum follicle-stimulating hormone (FSH) and decreased estrogen measurements at one-month intervals. [10] The anterior pituitary secretes FSH and LH at high levels to try to increase the low estrogen levels that are due to the dysfunction of the ovaries.
Levels of LH/FSH may be suppressed by a raised prolactin level, and are therefore not interpretable unless prolactin is low or normal. In men, the combination of low LH and FSH in combination with a low testosterone confirms LH/FSH deficiency; a high testosterone would indicate a source elsewhere in the body (such as a testosterone-secreting ...
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Low levels of growth hormone may present with low energy, body aches, or subtle wrinkling of the skin around the eyes or mouth. [6] [8] The symptoms of anti-diuretic hormone deficiency are increased thirst, excessive urination, headache, and fatigue. [13] Hematological changes might be seen as well such as anemia or low platelets ...
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