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In the synergistic response, the applied antibiotics work together to produce an effect more potent than if each antibiotic were applied singly. [1] Compare to the additive effect , where the potency of an antibiotic combination is roughly equal to the combined potencies of each antibiotic singly, and antagonistic effect, where the potency of ...
One or both ingredients may be antibiotics. [1] Antibiotic combinations are increasingly important because of antimicrobial resistance. [2] This means that individual antibiotics that used to be effective are no longer effective, [1] and because of the absence of new classes of antibiotic, they allow old antibiotics to be continue to be used. [2]
Doxycycline is less likely than other antibiotic drugs to cause Clostridioides difficile colitis. [73] An erythematous rash in sun-exposed parts of the body has been reported to occur in 7.3–21.2% of persons taking doxycycline as prophylaxis against malaria. One study examined the tolerability of various malaria prophylactic regimens and ...
Some people should consider taking an antibiotic as a morning-after pill to try to prevent certain sexually transmitted diseases, U.S. health officials recommended Tuesday. The Centers for Disease ...
[3] [41] [42] Immediate medical care is required upon the first signs of these adverse effects. [9] Similarly to other penicillins, amoxicillin has been associated with an increased risk of seizures. [3] [41] [43] [44] Amoxicillin-induced neurotoxicity has been especially associated with concentrations of greater than 110 mg/L. [45]
Antibiotics with less reliable but occasional (depending on isolate and subspecies) activity: occasionally penicillins including penicillin, ampicillin and ampicillin-sulbactam, amoxicillin and amoxicillin-clavulnate, and piperacillin-tazobactam (not all vancomycin-resistant Enterococcus isolates are resistant to penicillin and ampicillin)
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
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