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Antidepressant discontinuation syndrome is a relatively new phenomenon, being identified and described from 1950s onwards, in parallel with discovery and introduction of modern antidepressant medications, with the first MAOIs, and TCAs introduced from the 1950s onwards and the first SSRIs from the 1980s onwards. [8]
Sertraline (Zoloft) Paroxetine (Paxil, Pexeva) ... abruptly stopping SSRI treatment can result in antidepressant discontinuation syndrome, with symptoms like insomnia, mood disturbances and flu ...
Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal. [ 4 ] [ 5 ] [ 2 ] Symptoms in mild cases include high blood pressure and a fast heart rate ; usually without a fever . [ 2 ]
Abrupt interruption of sertraline treatment may result in withdrawal or discontinuation syndrome. Dizziness, insomnia, anxiety, agitation, and irritability are common symptoms. [ 86 ] It typically occurs within a few days from drug discontinuation and lasts a few weeks. [ 87 ]
Typically, brain zaps are associated with antidepressant discontinuation syndrome (ADS), which impacts an estimated 20 percent of people who abruptly stop or reduce their use of medication.
SSRIs are modern antidepressants often used as a first-line treatment for major depressive disorder. Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram ...
It is considered a distinct phenomenon from antidepressant discontinuation syndrome, post-acute withdrawal syndrome, and major depressive disorder, [70] [68] and should be distinguished from sexual dysfunction associated with depression [70] and persistent genital arousal disorder. [64]
FYI: The use of sertraline with other SSRIs could lead to an increased risk of a life-threatening condition called serotonin syndrome, according to the book StatPearls.