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Some cis eQTLs are detected in many tissue types but the majority of trans eQTLs are tissue-dependent (dynamic). [10] eQTLs may act in cis (locally) or trans (at a distance) to a gene. [11] The abundance of a gene transcript is directly modified by polymorphism in regulatory elements. Consequently, transcript abundance might be considered as a ...
Such expression QTLs (eQTLs) describe cis- and trans-controlling elements for the expression of often disease-associated genes. [16] Observed epistatic effects have been found beneficial to identify the gene responsible by a cross-validation of genes within the interacting loci with metabolic pathway- and scientific literature databases.
Trans-acting factors in alternative splicing in mRNA. Alternative splicing is a key mechanism that is involved in gene expression regulation. In the alternative splicing, trans-acting factors such as SR protein, hnRNP and snRNP control this mechanism by acting in trans. SR protein promotes the spliceosome assembly by interacting with snRNP(e.g. U1, U2) and splicing factors(e.g. U2AF65), and it ...
Very often, cis–trans stereoisomers contain double bonds or ring structures. In both cases the rotation of bonds is restricted or prevented. [4] When the substituent groups are oriented in the same direction, the diastereomer is referred to as cis, whereas when the substituents are oriented in opposing directions, the diastereomer is referred to as trans.
Diamond is ready for the holidays! The pigeon looked positively darling in his new Christmas sweater. So much so that he couldn't wait to put it on before the big day.
One of the most well known epigenetic mechanisms that proline isomerization plays a role in is the modification of histone tails, specifically those of histone H3. Fpr4 is a PPIase, in the FK507BP group, that exhibits catalytic activity at the proline positions 16, 30, and 38 (also written P16, P30, and P38 respectively) on the N-terminal region of histone H3 in Saccharomyces cerevisiae.
Next round is on NBA legend Charles Barkley!. Barkley, 61, earned the love of Fredonia, New York after he bought drinks for an entire local bar over the weekend after attending a college hockey game.
When comparing vegan, vegetarian, and omnivore diet types, researchers found that food quality and diversity may have the biggest impact on the health and structure of the gut microbiome.