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Alcohol tolerance is increased by regular drinking. [1] This reduced sensitivity to the physical effects of alcohol consumption requires that higher quantities of alcohol be consumed in order to achieve the same effects as before tolerance was established. Alcohol tolerance may lead to (or be a sign of) alcohol dependence. [1]
H7/h6 is a very common standard tolerance which gives a tight fit. The tolerances work in such a way that for a hole H7 means that the hole should be made slightly larger than the base dimension (in this case for an ISO fit 10+0.015−0, meaning that it may be up to 0.015 mm larger than the base dimension, and 0 mm smaller).
Tolerance analysis is the general term for activities related to the study of accumulated variation in mechanical parts and assemblies. Its methods may be used on other types of systems subject to accumulated variation, such as mechanical and electrical systems.
Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects.
Example of true position geometric control defined by basic dimensions and datum features. Geometric dimensioning and tolerancing (GD&T) is a system for defining and communicating engineering tolerances via a symbolic language on engineering drawings and computer-generated 3D models that describes a physical object's nominal geometry and the permissible variation thereof.
Note: in this context, IT does not mean Information Technology, but it is an Engineering term. An IT grade is an internationally accepted code system for tolerances on linear dimensions. Such code systems may be used to produce interchangeable parts. In engineering, the word tolerance refers to a range of allowable dimensions or values ...
However, metabolic tolerance can also lead to accumulation of the less toxic metabolized compound which can slowly damage the liver. With alcohol this generally leads to conditions such as alcoholic fatty liver disease. [11] Metabolic tolerance is not effective on all types of non-biological poisons.
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters .